Effects of the long noncoding RNA Malat1 on gene expression [Mouse430_2]

ABSTRACT: Malat1 is an abundant long noncoding RNA that localizes to nuclear bodies known as nuclear speckles, which contain a distinct set of pre-mRNA processing factors. Previous in vitro studies have demonstrated that Malat1 interacts with pre-mRNA splicing factors, including the serine- and arginine-rich (SR) family of proteins, and regulates a variety of biological processes, including cancer cell migration, synapse formation, cell cycle progression, and responses to serum stimulation. To address the physiological function of Malat1 in a living organism, we generated Malat1-KO (KO) mice using homologous recombination. Unexpectedly, the Malat1-KO mice were viable and fertile, showing no apparent phenotypes. Nuclear speckle markers were also correctly localized in cells that lacked Malat1. Howeve

ORGANISM(S): Mus musculus

SUBMITTER: Yuen Yan Ip 

PROVIDER: E-GEOD-37705 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress