Age-specific variation in immune response in Drosophila melanogaster has a genetic basis.

ABSTRACT: Immunosenescence, the age-related decline in immune system function, is a general hallmark of aging. While much is known about the cellular and physiological changes that accompany immunosenescence, we know very little about the genetic influences on this phenomenon. We used microarrays to determine genome-wide expression profiles in twelve inbred D. melanogaster lines that varied in their ability to to clear an E. coli infection at one and four weeks of age. Bacterially infected and sham-injected flies from each of the lines were frozen at -80M-BM-0C six hours post-injection at one and four weeks of age for use in the microarray study. Lines were chosen to represent the range of changes in age-specific clearance ability: four of the lines chosen exhibited the most dramatic decline in cl

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Jenny Drnevich 

PROVIDER: E-GEOD-37708 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress