MiR-155 regulates the ability of circulating cancer cells to colonize and establish metastasis

ABSTRACT: Abstract: Metastases are established through a complex multistep process by which tumor cells disseminate from the primary tumor and expand at distant sites. Traditionally, studies on metastasis have focused on proteins and protein-coding genes, but recently microRNAs (miRNAs) have achieved increasing interest. miRNAs involved in the metastatic process are poorly defined, and while the use of clinical tissue samples or in vitro assessment for study of the first phases of the metastatic process is not feasible; such processes may be studies using in vivo models created by inoculation of human cell lines into mice. We have used such a model system consisting of three isogenic human cancer cell lines that are equally tumorigenic in mice, but while two of these cell lines give rise to metastas

ORGANISM(S): Homo sapiens

SUBMITTER: Rolf Søkilde 

PROVIDER: E-GEOD-37719 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress