A novel miRNA produced during lytic HSV-1 infection is important for efficient replication in tissue culture.

ABSTRACT: We report a HSV-1 encoded miRNA present during lytic infection that influences replication efficiency in a tissue culture model. miRNAs were identified using high-throughput sequencing of HSV-1 infected epithelial cells. Functional assays were performed by mutating the miRNA coding region and testing grow of the mutant in vitro. Construction of a miRNA library and sequencing to reveal novel viral miRNAs from lytically infected cells

ORGANISM(S): Homo sapiens

SUBMITTER: April Burch 

PROVIDER: E-GEOD-37726 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress