Expression data from chick embryos overexpressing NEUROG2 or NEUROG2AQ in the neural tube

ABSTRACT: The proneural NEUROG2 is essential for neuronal commitment, cell cycle exit and neuronal differentiation. Characterizing genes networks regulated downstream of NEUROG2 is therefore of prime importance. To identify NEUROG2 early response genes, we combined gain of function in the neural tube with a global detection of modified transcripts using microarrays. We included in our study a mutant form of NEUROG2 (NEUROG2AQ) that cannot bind DNA and cannot trigger neurogenesis. Using this approach, we identified 942 genes modified at the onset of NEUROG2 activation. The global analysis of functions regulated by NEUROG2 allowed unmasking its rapid impact on cell cycle control. We found that NEUROG2 specifically represses a subset of cyclins acting at the G1 and S phases of the cell cycle, thereby i

ORGANISM(S): Gallus gallus

SUBMITTER: Sophie Vialar 

PROVIDER: E-GEOD-37782 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress