Human cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 2C)

ABSTRACT: Lipids comprise 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain and an animal model of MS to explore the role of the identified lipids in autoimmune demyelination. We found that autoantibodies in MS target a phosphate group in phosphatidylserine and oxidized phosphatidylcholine derivatives. Administration of these lipids ameliorated experimental autoimmune encephalomyelitis by suppressing activation and inducing apoptosis of autoreactive T cells, effects mediated by the lipids' saturated fatty-acid side chains. Thus, phospholipids represent a natural anti-inflamma

ORGANISM(S): Homo sapiens

SUBMITTER: William Robinson 

PROVIDER: E-GEOD-37826 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress