Sinus Microbiome Plays a Primary Role in Rhinosinusitis

ABSTRACT: Persistent mucosal inflammation and microbial infection are characteristic of Chronic Rhinosinusitis (CRS). Though mucosal microbiota dysbiosis is a characteristic feature of other chronic inflammatory diseases, the relationship between sinus microbiota composition and CRS is unknown. Here we demonstrate, using comparative microbiome profiling of a cohort of CRS patients and healthy subjects, that the sinus microbiota of CRS patients exhibit significantly reduced bacterial diversity. Characteristic of this community collapse is the depletion of multiple, phylogenetically distinct, Lactic Acid Bacteria and the concomitant increase in relative abundance of a single species, Corynebacterium tuberculostearicum. Recapitulating the conditions observed in our human cohort in a murine model confir

ORGANISM(S): human nasopharyngeal metagenome

SUBMITTER: Susan Lynch 

PROVIDER: E-GEOD-37850 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress