Gene expression profile in peritoneal macrophage stimulated with B-DNA or CpG-B

ABSTRACT: Toll-like receptor and RIG-I-like receptor classs may evoke or instruct a distinct type of response that is more reflective of the pathogen encountered. Although this issue may be critical to a better understanding of the regulation of immune responses to microbial infections, it has not been addressed through a direct, side-by-side comparison of the two receptor classes. To address this, we performed microarray analysis of mRNAs from peritoneal macrophages stimulated with a synthetic B-form DNA, poly(dA-dT)M-cM-^CM-;poly(dT-dA) ( B-DNA) or a CpG-B oligonucleotide, which respectively activates RLRs or TLR9, and identified B-DNA inducible genes and CpG-B inducible genes. Peritoneal macrophages from B6 mice were stimulated with B-DNA (10M-NM-

ORGANISM(S): Mus musculus

SUBMITTER: hideo negishi 

PROVIDER: E-GEOD-37854 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress