Dataset Information
Gene expression in IRF3-/- peritoneal macrophage infected with VSV
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: hideo negishi
PROVIDER: E-GEOD-37855 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses.
Nature immunology 20120520 7
Although the mechanisms by which innate pathogen-recognition receptors enhance adaptive immune responses are increasingly well understood, whether signaling events from distinct classes of receptors affect each other in modulating adaptive immunity remains unclear. We found here that the activation of cytosolic RIG-I-like receptors (RLRs) resulted in the selective suppression of transcription of the gene encoding the p40 subunit of interleukin 12 (Il12b) that was effectively induced by the activ ...[more]
