Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcruption profiling of human cerebellum, frontal cortex [BA4, BA9] and caudate nucleus HD tissue experiment

ABSTRACT: Post mortem human brain tissue comparison between HD patients and controls from 3 brain regions - cerebellum, frontal cortex [BA4, BA9] and caudate nucleus. Gene expression analysed using linear models from LIMMA package in Bioconductor suite. Experiment Overall Design: Large sample sizes were used to examine brain tissue gene expression at various stages of HD pathology. Three brain regions were profiled, compared and analysed for differential gene expression. The broad aim was to capture early stage gene expression changes in HD brains.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Lesley Jones Angela Hodges 

PROVIDER: E-GEOD-3790 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human brain has not previously been available. To elucidate the molecular phenotype of HD on a genome-wide scale, we compared mRNA profiles from 44 human HD brains with those from 36 unaffected controls using microarray analysis. Four brain regions were analyzed: caudate nucleus, cerebellum, prefrontal association cortex [Brodmann's area 9 (BA9  ...[more]

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