Expression profiling of palatal shelves in Tbx1 mutant mice

ABSTRACT: To assess the influence of Tbx1 on gene expression profile within the developing palate we performed a microarray screen using RNA isolated from dissected secondary palate shelves of E13.5 wild type, Tbx1+/- and Tbx1-/- mice. Significant differences were identified between genotypes, with a total of 67 genes demonstrating at least a 2-fold change (p<0.05) in expression. These were clustered into 5 groups, including those downregulated in mutant compared to wild type and heterozygote (n=36); those progressively downregulated from wild type to mutant (n=12); those upregulated in heterozygote and downregulated in mutant compared to wild type (n=2); those progressively upregulated from wild type to mutant (n=12) and those downregulated in heterozygote and upregulated in mutant compared to wild

ORGANISM(S): Mus musculus

SUBMITTER: Matthew Arno 

PROVIDER: E-GEOD-37904 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress