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AIP inactivation exerts its tumor-promoting action through defected GÎ±i signaling and elevated cyclic-AMP levels

ABSTRACT: Gene-level expression profiles of 7 Aip knock-out (triplicates from each) and 9 Aip wild-type mouse embryonic fibroblast cell lines were studied using Affymetrix GeneChip Mouse Exon 1.0 ST Arrays All samples were quantile-normalized by the RMA method (Robust Multichip Average) using re-mapped gene annotations from Brainarray Custom CDF files (MoEx10stv1, Version 14.1.0, http://brainarray.mbni.med.umich.edu/Brainarray/default.asp). A 2-way ANOVA was constructed to identify genes that differentially expressed between KO and WT samples. False discovery rate control (FDR) with Benjamini and Hochberg method was used to correct for multiple testing

ORGANISM(S): Mus musculus

SUBMITTER: Miika Mehine

PROVIDER: E-GEOD-37927 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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