Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

ABSTRACT: Differentiated cells acquire unique structural and functional traits through coordinated expression of lineage-specific genes. An extensive battery of genes encoding components of the synaptic transmission machinery and specialized cytoskeletal proteins is activated during neurogenesis, but the underlying regulation is not well understood. Here we show that genes encoding critical presynaptic proteins are transcribed at a detectable level in both neurons and non-neuronal cells. However, in non-neuronal cells, the splicing of 3M-bM-^@M-^Y-terminal introns within these genes is repressed by polypyrimidine tract-binding protein (Ptbp1). This inhibits the export of incompletely spliced mRNAs to the cytoplasm and triggers their nuclear degradation. Clearance of these intron-containing transcrip

ORGANISM(S): Mus musculus

SUBMITTER: Brad Friedman 

PROVIDER: E-GEOD-37933 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress