Expression analysis of tumor microenvironment in triple-negative breast carcinoma in xenograft model

ABSTRACT: Decorin, a member of the small leucine-rich proteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tumorigenesis by directly targeting and antagonizing multiple receptor tyrosine kinases, such as the EGFR and Met. This leads to potent and sustained signal attenuation, growth arrest, and angiostasis. We thus sought to evaluate the tumoricidal benefits of systemic decorin on a triple-negative orthotopic breast carcinoma xenograft model. To this end, we employed a novel high-density mixed expression array capable of differentiating and simultaneously measuring gene signatures of both Mus musculus (stromal) and Homo sapiens (epithelial) tissue origins. We found decorin modulated the differential expression of 374 genes within the stromal compartment

ORGANISM(S): Mus musculus

SUBMITTER: Renato Iozzo 

PROVIDER: E-GEOD-37937 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress