ERa-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Todd Miller
PROVIDER: E-GEOD-37955 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer.
Miller Todd W TW Balko Justin M JM Fox Emily M EM Ghazoui Zara Z Dunbier Anita A Anderson Helen H Dowsett Mitch M Jiang Aixiang A Smith R Adam RA Maira Sauveur-Michel SM Manning H Charles HC González-Angulo Ana M AM Mills Gordon B GB Higham Catherine C Chanthaphaychith Siprachanh S Kuba Maria G MG Miller William R WR Shyr Yu Y Arteaga Carlos L CL
Cancer discovery 20110720 4
Most estrogen receptor α (ER)-positive breast cancers initially respond to antiestrogens, but many eventually become estrogen-independent and recur. We identified an estrogen-independent role for ER and the CDK4/Rb/E2F transcriptional axis in the hormone-independent growth of breast cancer cells. ER downregulation with fulvestrant or small interfering RNA (siRNA) inhibited estrogen-independent growth. Chromatin immunoprecipitation identified ER genomic binding activity in estrogen-deprived cells ...[more]
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