The MTAP-CDKN2A Locus Confers Susceptibility to a Naturally Occurring Canine Cancer

ABSTRACT: Well-defined, closed breeding populations coupled with excessive disease predispositions among purebred domestic dog breeds offer unique advantages to genetic studies of disease susceptibility. Advantages offered by canine population substructure, combined with similarity to human disease in terms of clinical presentation and response to treatment, make the dog a particularly attractive system for finding genes associated with cancer. Cancers that have been difficult to study in human families or populations are of particular interest, especially those associated with one or a small number of breeds and a high level of occurrence. Histiocytic sarcoma (HS) is a rare and poorly understood neoplasm in humans, however it occurs in 15-25% of Bernese Mountain Dogs (BMD). By combining genome-wide

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Heidi Parker 

PROVIDER: E-GEOD-38011 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress