Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma (Illumina)

ABSTRACT: Inflammatory leiomyosarcoma (ILMS) is a soft tissue tumor that morphologically resembles conventional leiomyosarcoma (LMS) admixed with a prominent inflammatory infiltrate. Genetic data on ILMS are still limited but have suggested that this entity is characterized by hyperhaploidy (24-34 chromosomes). This low chromosome number is otherwise uncommon in neoplasia and has been found only in 0.2-0.3% of cytogenetically investigated tumors. Here, three ILMS were investigated using cytogenetic, SNP array and global gene expression analyses. All cases displayed a hyperhaploid origin. Combined with previously reported cases, hyperhaploidy has been found in six of seven cytogenetically investigated ILMS. The copy number distribution of individual chromosomes is clearly nonrandom; the hyperhaploid

ORGANISM(S): Homo sapiens

SUBMITTER: Karolin Nord 

PROVIDER: E-GEOD-38015 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress