Overexpression of Snail is associated with lymph node metastasis and poor prognosis in patients with gastric cancer

ABSTRACT: Epithelial-mesenchymal transition (EMT) is in the highlights as a significant role in tumor progression and invasion. Snail was known as the one of regulators of EMT in various malignant tumors. The aim of this study was to investigate the effect of Snail on invasiveness/migratory ability of gastric cancer cell lines and clinicopathological and prognostic significance of Snail over-expression using immunohistochemistry in tissue microarray of 314 gastric adenocarcinomas (GC). Differential gene expression in Snail over-expressed GC was investigated using cDNA microarray analysis. Silencing of Snail by ShRNA induced decreased of invasion, migration of gastric cancer cell lines. In contrast, over-expression of Snail induced increased invasiveness and migratory ability of gastric cancer cell l

ORGANISM(S): Homo sapiens

SUBMITTER: Chae Hwa Kwon 

PROVIDER: E-GEOD-38024 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress