Gene expression analysis of THP-1 cells co-cultured with platelet-like particles

ABSTRACT: Abstract. The role of platelets in hemostasis and thrombosis is clearly established; however, the mechanisms by which platelets mediate inflammatory and immune pathways are less well understood. Platelets interact and modulate the function of blood and vascular cells by releasing bioactive molecules. Although the platelet is anucleate, it contains transcripts that may mirror disease. Platelet mRNA is only associated with low-level protein translation, however, platelets have a unique membrane structure allowing for the passage of small molecules, leading to the possibility that its’ cytoplasmic RNA may be passed to nucleated cells. To examine this question, platelet-like particles with labeled RNA were co-cultured with vascular cells. Co-culture of platelet-like particles with activated

ORGANISM(S): Homo sapiens

SUBMITTER: Antonina Risitano 

PROVIDER: E-GEOD-38027 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress