Host Response Signature to Staphylococcus aureus alpha-Hemolysin

ABSTRACT: Staphylococcus aureus pneumonia causes significant morbidity and mortality. Alpha-hemolysin (Hla), a pore-forming cytotoxin of S. aureus, has been identified through animal models of pneumonia as a critical virulence factor that induces lung injury. In spite of considerable molecular knowledge of how this cytotoxin injures the host, the precise host response to Hla in the context of infection remains poorly understood. We employed whole-genome expression profiling of infected lung to define the host response to wild-type S. aureus compared with an Hla-deficient isogenic mutant in experimental pneumonia. These data provide a complete expression profile at four and at twenty-four hours post-infection, revealing a unique response to the toxin-expressing strain. Gene ontogeny analysis revealed

ORGANISM(S): Mus musculus

SUBMITTER: Tong Zhou 

PROVIDER: E-GEOD-38053 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress