Novel long non-coding RNAs are involved in cellular response to angiotensin II signaling

ABSTRACT: Angiotensin II (AngII) is a polypeptide hormone that plays a pivotal role in the regulation of blood pressure. In vascular smooth muscle cells (VSMCs), AngII signaling results in hypertrophy, proliferation, contraction, and migration, which ultimately promote atherosclerosis and hypertensive cardiovascular diseases. Recent studies have shown that fundamental biological processes such as cell proliferation and differentiation are mediated in part by the activities of long non-protein-coding RNAs (lncRNAs). In this study, we sought to identify lncRNAs that are involved in the response to AngII-signaling. Genome-wide analysis of de novo assembled transcripts from rat vascular smooth muscle cells (VSMCs) identified novel lncRNA as well as protein-coding transcripts which have not been previous

ORGANISM(S): Rattus norvegicus

SUBMITTER: Amy Leung 

PROVIDER: E-GEOD-38056 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress