Genomic (in)stability of the breast tumor microenvironment

ABSTRACT: The breast tumor microenvironment plays an active role in tumorigenesis. Molecular alterations, including epigenetic modifications to DNA, and changes in RNA and protein expression have been identified in tumor-associated stroma; however, there is considerable debate as to whether the stroma is characterized by genomic instability or whether detection of chromosomal alterations in the breast stroma is a reflection of technological artifact rather than the true genomic content of the tumor microenvironment. Methods: Surgically-removed breast stroma specimens from 112 women undergoing reductive mammoplasty (n=15), prophylactic mastectomy (N=6) or mastectomy for a diagnosis of breast disease (n=92) were frozen in optimal cutting temperature medium. Allelic imbalance (AI) analysis was performe

ORGANISM(S): Homo sapiens

SUBMITTER: Rachel Ellsworth 

PROVIDER: E-GEOD-38071 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress