Shutdown is a component of the Drosophila piRNA biogenesis machinery (smallRNA)

ABSTRACT: In animals, the piRNA pathway preserves the integrity of gametic genomes, guarding them against the activity of mobile genetic elements. This innate immune mechanism relies on distinct genomic loci, termed piRNA clusters, to provide a molecular definition of transposons, enabling their discrimination from genes. piRNA clusters give rise to long, single-stranded precursors which are processed into primary piRNAs through an unknown mechanism. These can engage in an adaptive amplification loop, the ping-pong cycle, to optimize the content of small RNA populations via the generation of secondary piRNAs. Many proteins have been ascribed functions in either primary biogenesis or the ping- pong cycle, though for the most part the molecular functions of proteins implicated in these pathways remain

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Benjamin Czech 

PROVIDER: E-GEOD-38089 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress