Constitutively active STAT5 recruits p53 to alternative transcriptional targets in myeloid cancers

ABSTRACT: In several cancer types, STAT (Signal transducer and activator of transcription) transcription factors are constitutively activated. We previously identified a target gene, LPP/miR-28 (LIM domain containing preferred translocation partner in lipoma), induced by constitutive activation of STAT5, but not by transient cytokine-activated STAT5. Here, we demonstrate in transformed hematopoietic cells that binding of both STAT5B and p53 to chromatin is required for transcriptional activity of an alternative LPP/miR-28 promoter. Using a genome-wide approach, we identified 463 genomic positions at promoter regions where STAT5B and p53 are co-localized on the chromatin. At these positions, p53 chromatin binding is dependent on persistent STAT5B activation. The transcriptional activity of selected

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Girardot 

PROVIDER: E-GEOD-38143 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress