Gene expression profiling of primary human hepatocytes treated with IFN-alpha or IFN-gamma

ABSTRACT: Approximately 50% of patients with chronic hepatitis C (CHC) have a sustained virologic response (SVR) to treatment with pegylated interferon (pegINF)-α and ribavirin. Non-response to treatment is associated with constitutively increased expression of IFN-stimulated genes (ISGs) in the liver. Treatment of patients with acute hepatitis C (AHC) is more effective, with SVR rates >90%. We investigated mechanisms of the different responses of patients with CHC and AHC to pegIFN-α therapy. We analyzed IFN signaling and ISG expression in liver samples from patients with acute hepatitis C (AHC), patients with chronic hepatitis (CHC), and individuals without hepatitis C (controls) using microarray, immunohistochemical, and protein analyses. Findings were compared with those from primary human hepat

ORGANISM(S): Homo sapiens

SUBMITTER: Zuzanna Makowska 

PROVIDER: E-GEOD-38147 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress