Xenobiotics shape the physiology and gene expression of the active human gut microbiome

ABSTRACT: The human gut is colonized by trillions of microorganisms that influence human health and disease through the metabolism of xenobiotics, including therapeutic drugs and antibiotics. The diversity and metabolic potential of the human gut microbiome have been extensively characterized, but it remains unclear which microorganisms are active and which perturbations can influence this activity. Here, we use flow cytometry, 16S rRNA gene sequencing, and metatranscriptomics to demonstrate that the human gut contains distinctive subsets of active and damaged microorganisms, primarily composed of Firmicutes, which display marked temporal variation. Short-term exposure to a panel of xenobiotics resulted in significant changes in the physiology and gene expression of this active microbiome. Xenobioti

ORGANISM(S): human gut metagenome

SUBMITTER: Peter Turnbaugh 

PROVIDER: E-GEOD-38151 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress