Dataset Information
Transcription profile in patients with cyanotic Tetralogy of Fallot undergoing corrective surgery using hyperoxic/standard cardiopulmonary bypass
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mohamed Ghorbel
PROVIDER: E-GEOD-38161 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Controlled reoxygenation cardiopulmonary bypass is associated with reduced transcriptomic changes in cyanotic tetralogy of Fallot patients undergoing surgery.
Physiological genomics 20120918 22
In cyanotic patients undergoing repair of heart defects, high level of oxygen during cardiopulmonary bypass (CPB) leads to greater susceptibility to myocardial ischemia and reoxygenation injury. This study investigates the effects of controlled reoxygenation CPB on gene expression changes in cyanotic hearts of patients undergoing surgical correction of tetralogy of Fallot (TOF). We randomized 49 cyanotic TOF patients undergoing corrective cardiac surgery to receive either controlled reoxygenatio ...[more]
