Unknown,Transcriptomics,Genomics,Proteomics

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Controlling Reoxygenation During Cardiopulmonary Bypass is Associated with Reduced Transcriptomic Changes in Cyanotic Patients with Tetralogy of Fallot Undergoing Heart Surgery

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Mohamed Ghorbel 

PROVIDER: E-GEOD-38177 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Controlled reoxygenation cardiopulmonary bypass is associated with reduced transcriptomic changes in cyanotic tetralogy of Fallot patients undergoing surgery.

Ghorbel Mohamed T MT   Mokhtari Amir A   Sheikh Maimuna M   Angelini Gianni D GD   Caputo Massimo M  

Physiological genomics 20120918 22

In cyanotic patients undergoing repair of heart defects, high level of oxygen during cardiopulmonary bypass (CPB) leads to greater susceptibility to myocardial ischemia and reoxygenation injury. This study investigates the effects of controlled reoxygenation CPB on gene expression changes in cyanotic hearts of patients undergoing surgical correction of tetralogy of Fallot (TOF). We randomized 49 cyanotic TOF patients undergoing corrective cardiac surgery to receive either controlled reoxygenatio  ...[more]

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