Orientia tsutsugamushi, the agent of scrub typhus, induces an inflammatory program in human macrophages

ABSTRACT: Scrub typhus is a life-threatening disease caused by Orientia tsutsugamushi, a bacterium that mainly infects endothelial cells in vitro and in vivo. Evidence suggests that the interaction of O. tsutsugamushi with myeloid cells may play a pivotal role in O. tsutsugamushi infection. We showed here that O. tsutsugamushi intensively replicated within human monocyte-derived macrophages. Bacterial organisms stimulated the expression of a large panel of genes including type I interferon, interferon-stimulated, inflammatory, apoptosis-related genes and induced an M1-type gene response in macrophages. This transcriptional signature was accompanied by functional consequences such as the release of inflammatory cytokines such as Tumor Necrosis Factor and interleukin-gamma. Live O. tsutsugamushi organ

ORGANISM(S): Homo sapiens

SUBMITTER: Julien Textoris 

PROVIDER: E-GEOD-38194 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress