Gene expression profile of chicken lung in response to Avian influenza virus challenge in broiler chickens

ABSTRACT: To determine the host response to AIV in chicken lungs, a whole chicken genome array was used to analyze RNA isolated from chicken lungs infected with AIV (4dpi) or medium control (NS). Dual-color, direct comparisons were carried between AIV infected and non-infected controls. Each comparison includes four biological replicates. There were 508 mRNAs (347 down-regulated) were differentially expressed following AIV infection. From the results, MX1, IL-8, IRF-7, TNFRS19 are identified as strong candidate genes involved in regulating the host response to AIV infection in the lungs of broiler chickens. Further gene specific knock-down assay is warranted to elucidate underlying mechanism of AIV infection regulation in the chicken. Dual-color, common reference comparisons were carried between AI

ORGANISM(S): Gallus gallus

SUBMITTER: Huaijun Zhou 

PROVIDER: E-GEOD-38197 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress