MicroRNA profiling in TGF? signaling and development of fibrosis.

ABSTRACT: End stage liver disease due to Hepatitis C Virus (HCV) infection is a major health concern worldwide. Liver fibrosis following chronic HCV infection plays a pivotal role in loss of liver function and end stage liver disease. However the dynamics and molecular events that lead to fibrosis in HCV infection are poorly defined. Therefore, we determined the influence of HCV infection in altering the miRNA expression levels which can modulate immune responses to HCV leading to fibrosis. Analysis of the miRNA expression profiles of HCV infected liver biopsies revealed that 45 miRNAs were differentially expressed in the HCV infected liver when compared to normal livers. In silico target prediction of these differentially expressed miRNAs indicated that their targets include chemokine/cytokine sig

ORGANISM(S): Homo sapiens

SUBMITTER: Nobish Varghese 

PROVIDER: E-GEOD-38226 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress