Activation of TGF-beta pathway by areca nut constituents: A possible cause of Oral submucous fibrosis.

ABSTRACT: To understand the role of areca nut constituents in manifestation of Oral submucous fibrosis, we studied gene expression profile in epithelial cells following areca nut water extract treatment. A comaprison with TGF-beta induced gene expression changes were performed as epithelial cells were predicted to be source of TGF-beta. Control Vs Areca nut 5 ug/ml water extract (5H) (2), Contro Vs TGF-beta (2), Control Vs ALK5 (TbetaRI inhibitor) (2), Control Vs 5H + ALK5 inhibitor (2). (2)- Biological duplicates.

ORGANISM(S): Homo sapiens

SUBMITTER: Neeraj KUMAR 

PROVIDER: E-GEOD-38227 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress