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Methylome Analysis of FF HPV+ and HPV- HNSCC samples

ABSTRACT: The analysis of the 6 methylomes by MeDIP-Seq comprise 3 HPV+ HNSCC samples and 3 HPV- HNSCC samples Analysis of the 6 methylomes, comprising 3 HPV+ HNSCC samples and 3 HPV- HNSCC samples

ORGANISM(S): Homo sapiens

SUBMITTER: Gareth Wilson

PROVIDER: E-GEOD-38263 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma.

Lechner Matthias M Fenton Tim T West James J Wilson Gareth G Feber Andrew A Henderson Stephen S Thirlwell Christina C Dibra Harpreet K HK Jay Amrita A Butcher Lee L Chakravarthy Ankur R AR Gratrix Fiona F Patel Nirali N Vaz Francis F O'Flynn Paul P Kalavrezos Nicholas N Teschendorff Andrew E AE Boshoff Chris C Beck Stephan S

Genome medicine 20130205 2

<h4>Background</h4>Human papillomavirus-positive (HPV+) head and neck squamous cell carcinoma (HNSCC) represents a distinct clinical and epidemiological condition compared with HPV-negative (HPV-) HNSCC. To test the possible involvement of epigenetic modulation by HPV in HNSCC, we conducted a genome-wide DNA-methylation analysis.<h4>Methods</h4>Using laser-capture microdissection of 42 formalin-fixed paraffin wax-embedded (FFPE) HNSCCs, we generated DNA-methylation profiles of 18 HPV+ and 14 HPV ...[more]

PMID: 23419152

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