In vivo disruption of Rb-E2F-Ezh2 signaling loop causes bladder cancer development

ABSTRACT: Bladder cancer (BC) is a highly prevalent human disease in which Rb pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here we show that the in vivo inactivation of all Rb family genes in the mouse urothelium is sufficient to initiate BC development. The characterization of the mouse tumors revealed multiple molecular features of human BC, including the activation of E2F transcription factor and subsequent Ezh2 expression, and the activation of several signaling pathways previously identified as highly relevant in urothelial tumors. Whole transcriptional characterizations of the mouse bladder tumors revealed a significant overlap with human BC samples, and a predominant role for Ezh2 in the down

ORGANISM(S): Homo sapiens

SUBMITTER: Ramón García-Escudero 

PROVIDER: E-GEOD-38264 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress