Effect of cFP on gene expression in Vibiro cholerae

ABSTRACT: Vibrio cholerae is a Gram negative, motile, facultative anaerobic bacterium, and the causative agent of cholera, a severe diarrhoeal disease, which untreated can rapidly lead to dehydration, hypotensive shock, and death. Cholera is a significant human disease that is estimated to affect 3-5 million people each year. The mechanism by which V. cholerae regulates virulence gene expression in vivo is unknown, but a number of studies have suggested that low molecular weight signally molecules may be important in modulating gene expression. cFP is a low molecular weight cyclic dipeptide produced by multiple Vibrio species. Evidence previously generated in our laboratory showed that cFP inhibited the production of the virulence factors cholera toxin (CT) and the toxin coregulated pilus (TCP) in O

ORGANISM(S): Vibrio cholerae O1 biovar El Tor str. N16961

SUBMITTER: James Bina 

PROVIDER: E-GEOD-38272 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress