Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression of mouse embryonic gonad [Nanos2_Stra8]

ABSTRACT: To examine whether the meiosis was solo factor responsible for the disruption of the male gonocyte differenitiation in the Nanos2-/- male germ cells, we deleted Stra8 function from Nanos2-null background and performed expression microarray analysis of the Nanos2+/-/Stra8+/- , Nanos2-/-/Stra8+/-, and Nanos2-/-/Stra8-/- male emnbryonic gonads at E14.5. Biological duplicates were examined at each stage, genotype, and sex for each experiment.

ORGANISM(S): Mus musculus

SUBMITTER: Rie Saba 

PROVIDER: E-GEOD-38294 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells.

Wu Quan Q   Kanata Kohei K   Saba Rie R   Deng Chu-Xia CX   Hamada Hiroshi H   Saga Yumiko Y  

Development (Cambridge, England) 20121205 2

Testicular development in the mouse is triggered in somatic cells by the function of Sry followed by the activation of fibroblast growth factor 9 (FGF9), which regulates testicular differentiation in both somatic and germ cells. However, the mechanism is unknown. We show here that the nodal/activin signaling pathway is activated in both male germ cells and somatic cells. Disruption of nodal/activin signaling drives male germ cells into meiosis and causes ectopic initiation of female-specific gen  ...[more]

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