RNA sequencing revealed novel actors of the acquisition of drug resistance in Candida albicans

ABSTRACT: Drug susceptible clinical isolates of Candida albicans frequently become highly tolerant to drugs during chemotherapy, with dreadful consequences on patient health. We used RNA sequencing (RNA-seq) to analyze the transcriptomes of a CDR (Candida Drug Resistance) strain and its isogenic drug sensitive counterpart. RNA-seq unveiled differential expression of 228 genes including a) genes previously identified as involved in CDR, b) genes not previously associated to the CDR phenotype, and c) novel transcripts whose function as a gene is uncharacterized. In particular, we show for the first time that CDR acquisition is correlated with an overexpression of the transcription factor encoding gene CZF1. CZF1 null mutants were sensitive to many drugs, independently of known multidrug resistance me

ORGANISM(S): Candida albicans

SUBMITTER: sophie lemoine 

PROVIDER: E-GEOD-38298 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress