DEPTOR cell-autonomously promotes adipogenesis and associates with obesity

ABSTRACT: An understanding of the mechanisms regulating white adipose tissue (WAT) formation is key for developing of new tools to treat obesity and its related diseases. Here, we identify DEPTOR as a positive regulator of adipogenesis whose expression is associated with obesity. In a polygenic mouse model of obesity/leanness, Deptor is part of the Fob3a QTL linked to obesity and we fine that Deptor is the highest priority candidate gene regulating WAT accumulation in this model. Using a doxycycline-inducible mouse model for Deptor overexpression, we confirmed that Deptor promotes WAT expansion in vivo. DEPTOR expression is elevated in WAT of obese humans and strongly correlates with the degree of obesity. We show that DEPTOR is induced during adipogenesis and that its overexpression cell-autonomous

ORGANISM(S): Mus musculus

SUBMITTER: Peter Juvan 

PROVIDER: E-GEOD-38321 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress