Short-term, high fat-feeding-induced changes in white adipose tissue gene expression are highly predictive for long-term changes

ABSTRACT: Using standardized, semipurified diets is a crucial factor for reproducibility of experimental nutritional studies. For the purpose of comparability and integration of research, two European consortia, Mitofood and BIOCLAIMS, proposed an AIN-93-based standard reference diet, the standardized BIOCLAIMS low-fat diet (LFD) as well as a high-fat diet (HFD). In order to evaluate the BIOCLAIMS LFD and HFD, we performed short-term (5 days) and long-term (12 weeks) feeding experiments using male C57BL/6 mice. The HFD has the same composition as the LFD except the fat content is increased to 40% energy in exchange for carbohydrates. Both diets were accepted by the animals and proof of principle was given that the BIOCLAIMS HFD increases body weight and body fat and affects glucose homeostasis. Shor

ORGANISM(S): Mus musculus

SUBMITTER: Evert van Schothorst 

PROVIDER: E-GEOD-38337 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress