Targeted disruption of BMAL1 in the peripheral reproductive axis results in infertility in female mice.

ABSTRACT: The product of the Bmal1 locus is an essential component of the circadian clock that plays important roles in various aspects of reproductive biology, and its disruption results in infertility. In an effort to identify the identity of the tissue specific clock that is responsible for this infertility, we used the steroidogenic factor-1 (Sf1) promoter to drive Cre-mediated recombination and genetically delete Bmal1 within cells of the reproductive axis. We show that Bmal1 within the reproductive axis of females is essential for normal fertility through its role in maintaining implantation, but is not required for normal estrous cycling. At the root of this biology appears to be a defect in the regulation of ovarian steroidogenic acute regulator (StAR) and its role in maintaining progesteron

ORGANISM(S): Mus musculus

SUBMITTER: Brian Johnson 

PROVIDER: E-GEOD-38365 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress