Rhesus monkey cumulus cells revert to a mural granulosa cell state following an ovulatory stimulus

ABSTRACT: Follicular somatic cells (mural granulosa cells and cumulus cells) and the oocyte communicate through paracrine interactions and through direct gap junctions between oocyte and cumulus cells. Considering that mural and cumulus cells arise through a common developmental pathway and that their differentiation is essential to reproductive success, understanding how these cells differ is a key aspect to understanding their critical functions. Changes in global gene expression before and after an ovulatory stimulus were compared between cumulus and mural granulosa cells to test the hypothesis that mural and cumulus cells are highly differentiated at the time of an ovulatory stimulus and further differentiate during the periovulatory interval. The transcriptomes of the two cell types were marked

ORGANISM(S): Macaca mulatta

SUBMITTER: Young Lee 

PROVIDER: E-GEOD-38387 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress