Gene expression changes in the fetal rhesus monkey uterus from early to late gestation and the effects of in utero exposure to BPA

ABSTRACT: We used the rhesus monkey (Macaca mulatta) as our animal model for the current study with two goals: to characterize the changes in histology and gene expression from early to late gestation (prenatal uterine organogenesis) and to determine if there are effects of prenatal exposure to bisphenol A (BPA) on the developing female uterus. Pregnant rhesus monkeys carrying a female fetus (N=22) were divided into two experimental groups, based on gestational timing: 'early' (N=10) and 'late' (N=12). These groups were then equally sub-divided into control (unexposed) and BPA (exposed) groups (5 Early Control, 5 Early BPA-exposed, 6 Late Control and 6 Late BPA-exposed.) The BPA-exposed monkeys received a deuterated BPA (dBPA, CDN Isotopes, Quebec, Canada) fruit treat on a daily basis, at a dose of

ORGANISM(S): Macaca mulatta

SUBMITTER: NIEHS Microarray Core 

PROVIDER: E-GEOD-38421 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress