Transcriptional perturbations caused by tumor virus proteins

ABSTRACT: Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply as the result of individual genomic variations. Genome sequencing efforts have identified numerous germline mutations associated with cancer predisposition and large numbers of somatic genomic alterations. However, it remains challenging to distinguish between background, or “passenger” and causal, or “driver” cancer mutations in these datasets. Human viruses intrinsically depend on their host cell during the course of infection and can elicit pathological phenotypes similar to those arising from mutations. To test the hypothesis that genomic variations and tumour virus

ORGANISM(S): Homo sapiens

SUBMITTER: Megha Padi 

PROVIDER: E-GEOD-38467 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress