Arthritis and Rheumatism
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Cornelis Verweij
PROVIDER: E-GEOD-3848 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Rheumatoid arthritis is a heterogeneous disease: evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues.
van der Pouw Kraan Tineke C T M TC van Gaalen Floris A FA Kasperkovitz Pia V PV Verbeet Nicolette L NL Smeets Tom J M TJ Kraan Maarten C MC Fero Mike M Tak Paul-Peter PP Huizinga Tom W J TW Pieterman Elsbet E Breedveld Ferdinand C FC Alizadeh Ash A AA Verweij Cornelis L CL
Arthritis and rheumatism 20030801 8
<h4>Objective</h4>To generate a molecular description of synovial tissue from rheumatoid arthritis (RA) patients that would allow us to unravel novel aspects of pathogenesis and to identify different forms of disease.<h4>Methods</h4>We applied complementary DNA microarray analysis to profile gene expression, with a focus on immune-related genes, in affected joint tissues from RA patients and in tissues from osteoarthritis (OA) patients as a control. To validate microarray data, real-time polymer ...[more]
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