Unknown,Transcriptomics,Genomics,Proteomics

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A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes [HumanHT-12 V3.0]


ABSTRACT: Gene expression analyses in whole blood reveal a network of genes related to schizophrenia Weighted gene co-expression analyses applied to human whole blood gene expression data of schizophrenia cases and healthy controls

ORGANISM(S): Homo sapiens

SUBMITTER: Simone de Jong 

PROVIDER: E-GEOD-38484 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes.

de Jong Simone S   Boks Marco P M MP   Fuller Tova F TF   Strengman Eric E   Janson Esther E   de Kovel Carolien G F CG   Ori Anil P S AP   Vi Nancy N   Mulder Flip F   Blom Jan Dirk JD   Glenthøj Birte B   Schubart Chris D CD   Cahn Wiepke W   Kahn René S RS   Horvath Steve S   Ophoff Roel A RA  

PloS one 20120627 6


Despite large-scale genome-wide association studies (GWAS), the underlying genes for schizophrenia are largely unknown. Additional approaches are therefore required to identify the genetic background of this disorder. Here we report findings from a large gene expression study in peripheral blood of schizophrenia patients and controls. We applied a systems biology approach to genome-wide expression data from whole blood of 92 medicated and 29 antipsychotic-free schizophrenia patients and 118 heal  ...[more]

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