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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE38481: A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes [HumanRef-8 v3.0] GSE38484: A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes [HumanHT-12 V3.0] Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Simone de Jong

PROVIDER: E-GEOD-38485 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes.

de Jong Simone S Boks Marco P M MP Fuller Tova F TF Strengman Eric E Janson Esther E de Kovel Carolien G F CG Ori Anil P S AP Vi Nancy N Mulder Flip F Blom Jan Dirk JD Glenthøj Birte B Schubart Chris D CD Cahn Wiepke W Kahn René S RS Horvath Steve S Ophoff Roel A RA

PloS one 20120627 6

Despite large-scale genome-wide association studies (GWAS), the underlying genes for schizophrenia are largely unknown. Additional approaches are therefore required to identify the genetic background of this disorder. Here we report findings from a large gene expression study in peripheral blood of schizophrenia patients and controls. We applied a systems biology approach to genome-wide expression data from whole blood of 92 medicated and 29 antipsychotic-free schizophrenia patients and 118 heal ...[more]

PMID: 22761806

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