Regulatory element copy number differences shape primate expression profiles.

ABSTRACT: Gene expression differences are shaped by selective pressures and contribute to phenotypic differences between species. We identified 964 copy number differences (CNDs) of conserved sequences across 3 primate species and examined their potential effects on gene expression profiles. Samples with copy number different genes had significantly different expression than samples with neutral copy number. Genes encoding regulatory molecules differed in copy number and were associated with significant expression differences. Additionally, we identified 127 CNDs which were processed pseudogenes and some of which were expressed. Furthermore, there were copy number different regulatory regions such as ultraconserved elements and long intergenic noncoding RNAs with the potential to affect expression.

ORGANISM(S): Pan troglodytes

SUBMITTER: Darren Cusanovich 

PROVIDER: E-GEOD-38572 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress