Brain transcriptional and epigenetic associations with the autistic phenotype (methylation data)

ABSTRACT: Autism is a common neurodevelopmental syndrome. Numerous rare genetic etiologies are reported; most cases are idiopathic. To uncover important gene dysregulation in autism, we analyzed carefully selected idiopathic autistic and control cerebellar and BA19 (occipital) brain tissues using high-resolution whole genome gene expression and DNA methylation microarrays. No changes in DNA methylation were identified in autistic brain but gene expression abnormalities in two areas of metabolism were apparent: down-regulation of genes of mitochondrial oxidative phosphorylation and of protein translation. We also found associations between specific behavioral domains of autism and specific brain gene expression modules related to myelin/myelination, inflammation/immune response and purinergic signali

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Ginsberg 

PROVIDER: E-GEOD-38608 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress