Transcriptional profiling of FeHm effects on Haemophilus influenzae R2846

ABSTRACT: Recently described microarray studies have defined the genes that are regulated in response to iron and heme levels in three isolates of Haemophilus influenzae. Comparison of the data sets have allowed us to develop a putative core iron/heme modulon. Included in the core modulon are thirty seven genes that are preferentially expressed under iron/heme limitation. The majority of these genes are involved with iron and or heme acquisition such as hitA, tonB, exbD, exbB, hgpB, hgpC and the hxu and tbp operons. In addition, we identified several other loci with roles potentially related to iron and heme metabolism such as protection against oxidative stress, iron and heme storage and detoxification and biofilm formation. In this report, we describe the further definition of the core iron/h

ORGANISM(S): Haemophilus influenzae

SUBMITTER: Timothy VanWagoner 

PROVIDER: E-GEOD-38638 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress