DamID profiling of neural transcription factor (Abrupt and Knot) binding in Drosophila melanogaster embryos

ABSTRACT: Paper abstract: The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of isolated these neurons. Their profiles were similarly enriched in cell-type-specific enhancers of genes implicated in neural development. We identified a total of 429 target genes, of which 56 were common to Ab and Kn; these targets included genes necessary to shape dendritic arbors in either or both of the two sensory subtypes. Furthermore, a common target gene, encoding the cell adhesion molecule Ten-m, was expressed more strongly in class I than IV, and this differential was critical to the class-selective dir

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Yukako Hattori 

PROVIDER: E-GEOD-38659 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress